A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA.

ABSTRACT: With the aim of developing a sensitizer for photodynamic therapy, a previously reported luminescent dinuclear complex that functions as a DNA probe in live cells was modified to produce a new iso-structural derivative containing Ru^II(TAP)₂ fragments (TAP = 1,4,5,8-tetraazaphenanthrene). The structure of the new complex has been confirmed by a variety of techniques including single crystal X-ray analysis. Unlike its parent, the new complex displays Ru → L-based ³MLCT emission in both MeCN and water. Results from electrochemical studies and emission quenching experiments involving guanosine monophosphate are consistent with an excited state located on a TAP moiety. This hypothesis is further supported by detailed DFT calculations, which take into account solv

SUBMITTER: Archer SA 

PROVIDER: S-EPMC6430095 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature