Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis.

ABSTRACT:

Background

Sjogren's syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However, this association remains controversial. This meta-analysis aimed to evaluate the risk of thyroid disease in patients with SS.

Methods

We performed this systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and SS. The results were subjected to meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (CIs).

Results

The eight articles in

SUBMITTER: Sun X 

PROVIDER: S-EPMC6430100 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature