Hepatocytes direct the formation of a pro-metastatic niche in the liver.

ABSTRACT: The liver is the most common site of metastatic disease¹. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a 'pro-metastatic' niche that supports the spread of tumour cells to the liver^2,3. The mechanisms that direct the formation of this niche are poorly understood. Here we show that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth. During early pancreatic tumorigenesis in mice, hepatocytes show activation of signal transducer and activator of transcription 3 (STAT3) signalling and increased production of serum amyloid A1 a

SUBMITTER: Lee JW 

PROVIDER: S-EPMC6430113 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature