Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

ABSTRACT: Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10^-13) and African ancestries (rs2066702; P = 2.2 × 10^-9). Significa

SUBMITTER: Walters RK 

PROVIDER: S-EPMC6430207 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature