Chronic stress produces enduring sex- and region-specific alterations in novel stress-induced c-Fos expression.

ABSTRACT: Prolonged or repeated exposure to stress increases risk for a variety of psychological disorders, many of which are marked by dysfunction of corticolimbic brain regions. Notably, women are more likely than men to be diagnosed with these disorders, especially when onset of symptoms follows stressful life events. Using rodent models, investigators have recently begun to elucidate sex-specific changes in the brain and behavior that occur immediately following chronic stress. However, little is known regarding the lasting sequelae of chronic stress, as well as how potential changes may impact responsivity to future stressors. We recently demonstrated that male and female rats show different patterns of dendritic reorganization in medial prefrontal cortex in the days following chronic stress. H

SUBMITTER: Moench KM 

PROVIDER: S-EPMC6430515 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature