Sex differences in corticotropin releasing factor regulation of medial septum-mediated memory formation.

ABSTRACT: Stress can disrupt memory and contribute to cognitive impairments in psychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder. These diseases are more common in men than in women, with men showing greater cognitive impairments. Mnemonic deficits induced by stress are mediated, in part, by corticotropin releasing factor (CRF). However, where CRF is acting to regulate memory, and sex differences therein, is understudied. Here we assessed whether CRF in the medial septum (MS), which projects to the hippocampus, affected memory formation in male and female rats. CRF in the MS did not alter hippocampal-independent object recognition memory, but impaired hippocampal-dependent object location memory in both sexes. Interestingly, males were more sensitive than fe

SUBMITTER: Wiersielis KR 

PROVIDER: S-EPMC6430617 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature