Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry.

ABSTRACT: There have been considerable recent advances in understanding the genetic architecture of Tourette syndrome (TS) as well as its underlying neurocircuitry. However, the mechanisms by which genetic variation that increases risk for TS-and its main symptom dimensions-influence relevant brain regions are poorly understood. Here we undertook a genome-wide investigation of the overlap between TS genetic risk and genetic influences on the volume of specific subcortical brain structures that have been implicated in TS. We obtained summary statistics for the most recent TS genome-wide association study (GWAS) from the TS Psychiatric Genomics Consortium Working Group (4644 cases and 8695 controls) and GWAS of subcortical volumes from the ENIGMA consortium (30,717 individuals). We also undertook anal

SUBMITTER: Mufford M 

PROVIDER: S-EPMC6430767 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature