Ontology highlight
ABSTRACT:
SUBMITTER: Saito H
PROVIDER: S-EPMC6430773 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190322 1
Osteoporosis is caused by increased bone resorption and decreased bone formation. Intermittent administration of a fragment of Parathyroid hormone (PTH) activates osteoblast-mediated bone formation and is used in patients with severe osteoporosis. However, the mechanisms by which PTH elicits its anabolic effect are not fully elucidated. Here we show that the absence of the homeodomain protein TG-interacting factor 1 (Tgif1) impairs osteoblast differentiation and activity, leading to a reduced bo ...[more]