Ontology highlight
ABSTRACT:
SUBMITTER: Sachs P
PROVIDER: S-EPMC6430823 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190322 1
Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key factor in the control of ERVs in embryonic stem cells. SMARCAD1 is enriched at ERV subfamilies class I and II, particularly at active intracisternal A-type particles (IAPs), where it preserves repressive histone methylation marks. Depletion of SMARCAD1 results in de-repression of IAPs and adjacent genes ...[more]