Dataset Information

The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.

ABSTRACT:

Background

Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD.

Hypothesis

Accumulation of IS is related to FGF-23 secretion in cats with CKD.

Animals

Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.

Methods

The concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months.

Results

Plasma IS and FGF-23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF-23 and phosphate. When the renal progression group was compared with the non-progression group, both IS and FGF-23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF-23 predicted renal progression at a level >0.9.

Conclusions and clinical importance

Both FGF-23 and IS are associated with phosphate metabolism and CKD progression.

SUBMITTER: Liao YL

PROVIDER: S-EPMC6430881 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.

Liao Yu-Lun YL Chou Chi-Chung CC Lee Ya-Jane YJ

Journal of veterinary internal medicine 20190218 2

<h4>Background</h4>Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD.<h4>Hypothesis</h4>Accumulation of IS is related to FGF-23 secretion in cats with CKD.<h4>Animals</h4>Twenty clinically ...[more]

PMID: 30779214

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Project description:ObjectivesThis study undertook a scoping review of research on blood fibroblast growth factor 23 (FGF-23) concentrations in healthy non-azotemic cats and cats with chronic kidney disease (CKD) to describe the volume and nature of existing literature, to determine whether published studies provide adequate evidence to support the use of FGF-23 as a biomarker in clinical practice and to identify any existing gaps in knowledge.MethodsPRISMA Extension for Scoping Reviews guidelines were used to design and perform the scoping review. Online databases were used to identify observational and clinical studies of blood FGF-23 concentrations in healthy cats and cats with CKD published before December 2022. Study and population characteristics and descriptive data on FGF-23 concentrations were extracted.ResultsA total of 205 publications were reviewed; 17 were retained for inclusion. Most studies were retrospective. Most studies included cats with International Renal Interest Society stage 2-4 CKD, with some variation. Key concepts explored in the literature include FGF-23 concentrations by CKD stage, effect of dietary phosphate restriction on FGF-23 concentrations, relationship between FGF-23 concentrations and blood phosphorus, calcium and magnesium concentrations, and FGF-23 concentrations in cats with progressive CKD. FGF-23 concentrations tended to be higher in cats with CKD compared with healthy cats, with an overlap between healthy and CKD populations, and there was significant variation within stages of CKD.Conclusions and relevanceFGF-23 is a biomarker of interest for the management and monitoring of phosphate overload in cats. Studies support several potential clinical applications for measuring FGF-23 concentration in practice; however, evidence is limited. Research on FGF-23 in cats with CKD would benefit from longitudinal, prospective studies that standardize CKD diagnosis and categorize cats by stage using current guidelines. Studies should include cats with early-stage, non-azotemic CKD and use commercially available assays so such results are comparable across studies.

Dataset Information

The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.

Background

Hypothesis

Animals

Methods

Results

Conclusions and clinical importance

Publications

The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.

Similar Datasets

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