The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.

ABSTRACT:

Background

Indoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD.

Hypothesis

Accumulation of IS is related to FGF-23 secretion in cats with CKD.

Animals

Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.

Methods

The concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentrat

SUBMITTER: Liao YL 

PROVIDER: S-EPMC6430881 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature