Pharmacokinetics of meloxicam after oral administration of a granule formulation to healthy horses.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drugs are administered in horses for several systemic diseases. Selective cyclooxygenase-2 inhibitors are preferred because of lower risk of adverse effects. Several meloxicam formulations have been tested in horses, but a recently marketed granule oral formulation has not been studied.

Objective

To characterize the pharmacokinetics of a novel granule meloxicam formulation in fasted and fed horses, and to compare pharmacokinetic features with oral suspension and tablets.

Animals

Seven healthy adult horses.

Methods

Meloxicam was administered at 0.6 mg/kg in fasted or fed horses. Blood samples were collected for pharmacokinetic analysis, and vital signs, hematology, and biochemistry variables were monitored for 72 hours.<

SUBMITTER: Mendoza FJ 

PROVIDER: S-EPMC6430890 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature