Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies.

ABSTRACT:

Background

Ponies are highly susceptible to metabolic derangements including hyperinsulinemia, insulin resistance, and adiposity.

Hypothesis/objectives

Genetic loci affecting height in ponies have pleiotropic effects on metabolic pathways and increase the susceptibility to equine metabolic syndrome (EMS).

Animals

Two hundred ninety-four Welsh ponies and 529 horses.

Methods

Retrospective study of horses phenotyped for metabolic traits. Correlations between height and metabolic traits were assessed by Pearson's correlation coefficients. Complementary genome-wide analysis methods were used to identify a region of interest (ROI) for height and metabolic traits, determine the fraction of heritability contributed by the ROI, and identify candidate genes.

Results</

SUBMITTER: Norton EM 

PROVIDER: S-EPMC6430908 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature