Time course and prognostic value of serum GFAP, pNFH, and S100β concentrations in dogs with complete spinal cord injury because of intervertebral disc extrusion.

ABSTRACT:

Background

A noninvasive biomarker is needed to predict recovery from severe spinal cord injury (SCI) because of thoracolumbar intervertebral disc extrusion (TL-IVDE). Proteins released from neural and glial cells can be detected in the blood and show promise as prognostic tools, but their concentration is influenced by time after injury.

Hypothesis/objectives

Serum concentrations of glial fibrillary acidic protein (GFAP), phosphorylated neurofilament heavy chain (pNFH), and S100β will follow different time courses; measurement of combinations of these proteins will predict outcome.

Animals

Thirty-one dogs with TL-IVDE causing paralysis with no pain perception.

Methods

Prospective study. Serum samples were taken at presentation and intervals over 56 days and ba

SUBMITTER: Olby NJ 

PROVIDER: S-EPMC6430936 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature