Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa.

ABSTRACT: Vaccines for Pseudomonas aeruginosa have been of longstanding interest to immunologists, bacteriologists, and clinicians, due to the widespread prevalence of hospital-acquired infection. As P. aeruginosa becomes increasingly antibiotic resistant, there is a dire need for novel treatments and preventive vaccines. Despite intense efforts, there currently remains no vaccine on the market to combat this dangerous pathogen. This article summarizes current and past vaccines under development that target various constituents of P. aeruginosa. Targeting lipopolysaccharides and O-antigens have shown some promise in preventing infection. Recombinant flagella and pili that target TLR5 have been utilized to combat P. aeruginosa by blocking its motility and adhesion. The typ

SUBMITTER: Hoggarth A 

PROVIDER: S-EPMC6431001 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature