Conserved and specific features of Streptococcus pyogenes and Streptococcus agalactiae transcriptional landscapes.

ABSTRACT:

Background

The human pathogen Streptococcus pyogenes, or group A Streptococcus, is responsible for mild infections to life-threatening diseases. To facilitate the characterization of regulatory networks involved in the adaptation of this pathogen to its different environments and their evolution, we have determined the primary transcriptome of a serotype M1 S. pyogenes strain at single-nucleotide resolution and compared it with that of Streptococcus agalactiae, also from the pyogenic group of streptococci.

Results

By using a combination of differential RNA-sequencing and oriented RNA-sequencing we have identified 892 transcription start sites (TSS) and 885 promoters in the S. pyogenes M1 strain S119. 8.6% of S. pyogenes mRNAs were leaderless, among which 81% were also classi

SUBMITTER: Rosinski-Chupin I 

PROVIDER: S-EPMC6431027 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature