Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation.

ABSTRACT: Long-term intracellular symbiosis (or endosymbiosis) is widely distributed across invertebrates and is recognized as a major driving force in evolution. However, the maintenance of immune homeostasis in organisms chronically infected with mutualistic bacteria is a challenging task, and little is known about the molecular processes that limit endosymbiont immunogenicity and host inflammation. Here, we investigated peptidoglycan recognition protein (PGRP)-encoding genes in the cereal weevil Sitophilus zeamais's association with Sodalis pierantonius endosymbiont. We discovered that weevil pgrp-lb generates three transcripts via alternative splicing and differential regulation. A secreted isoform is expressed in insect tissues under pathogenic conditions through activation

SUBMITTER: Maire J 

PROVIDER: S-EPMC6431197 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature