Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels.

ABSTRACT: Lipid nanovesicles are widely present as transport vehicles in living organisms and can serve as efficient drug delivery vectors. It is known that the size and surface charge of nanovesicles can affect their diffusion behaviors in biological hydrogels such as mucus. However, how temperature effects, including those of both ambient temperature and phase transition temperature (T_m), influence vehicle transport across various biological barriers outside and inside the cell remains unclear. Here, we utilize a series of liposomes with different T_m as typical models of nanovesicles to examine their diffusion behavior in vitro in biological hydrogels. We observe that the liposomes gain optimal diffusivity when their T_m is around the ambient te

SUBMITTER: Yu M 

PROVIDER: S-EPMC6431219 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature