MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons.

ABSTRACT: Homeostatic synaptic scaling is a negative feedback response to fluctuations in synaptic strength induced by developmental or learning-related processes, which maintains neuronal activity stable. Although several components of the synaptic scaling apparatus have been characterized, the intrinsic regulatory mechanisms promoting scaling remain largely unknown. MicroRNAs may contribute to posttranscriptional control of mRNAs implicated in different stages of synaptic scaling, but their role in these mechanisms is still undervalued. Here, we report that chronic blockade of glutamate receptors of the AMPA and NMDA types in hippocampal neurons in culture induces changes in the neuronal mRNA and miRNA transcriptomes, leading to synaptic upscaling. Specifically, we show that synaptic activity bloc

SUBMITTER: Silva MM 

PROVIDER: S-EPMC6431224 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature