Lipid transporter TMEM24/C2CD2L is a Ca²⁺-regulated component of ER-plasma membrane contacts in mammalian neurons.

ABSTRACT: Close appositions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are a general feature of all cells and are abundant in neurons. A function of these appositions is lipid transport between the two adjacent bilayers via tethering proteins that also contain lipid transport modules. However, little is known about the properties and dynamics of these proteins in neurons. Here we focused on TMEM24/C2CD2L, an ER-localized SMP domain containing phospholipid transporter expressed at high levels in the brain, previously shown to be a component of ER-PM contacts in pancreatic β-cells. TMEM24 is enriched in neurons versus glial cells and its levels increase in parallel with neuronal differentiation. It populates ER-PM contacts in resting neurons, but elevations of cytosolic Ca

SUBMITTER: Sun EW 

PROVIDER: S-EPMC6431226 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature