High virulence gene diversity in Streptococcus pyogenes isolated in Central Italy.

ABSTRACT: Globally, Streptococcus pyogenes poses a continuous burden on human health, causing both self-limiting and life-threatening diseases. Therefore, studying the profile of virulence genes and their combinations is essential to monitor the epidemiology and pathogenic potential of this important species. Thus, the aim of this study was to analyze related genetic features of clinical strains collected in Italy in 2012 in order to obtain a valid picture of their virulence profile that could be compared to similar studies made in other countries approximately in the same period. We conducted emm typing and fibronectin-collagen-T antigen (FCT) region typing in 122 Streptococcus pyogenes strains. Furthermore, several additional virulence genes were screened by polymerase chain r

SUBMITTER: Bencardino D 

PROVIDER: S-EPMC6431245 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature