Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca²⁺ Signaling and Re-Epithelialization after Wounding.

ABSTRACT: Extracellular Ca²⁺ (Ca²⁺_o) is a crucial regulator of epidermal homeostasis and its receptor, the Ca²⁺-sensing receptor (CaSR), conveys the Ca²⁺_o signals to promote keratinocyte adhesion, differentiation, and survival via activation of intracellular Ca²⁺ (Ca²⁺_i) and E-cadherin-mediated signaling. Here, we took genetic loss-of-function approaches to delineate the functions of CaSR in wound re-epithelialization. Cutaneous injury triggered a robust CaSR expression and a surge of Ca²⁺_i in epidermis. CaSR and E-cadherin were co-expressed at the cell-cell membrane between migratory keratinocytes in the nascent epithelial tongues. Blocking the expression of CaSR or E-cadherin in

SUBMITTER: Tu CL 

PROVIDER: S-EPMC6431556 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature