γδ T Cells Modulate Myeloid Cell Recruitment but Not Pain During Peripheral Inflammation.

ABSTRACT: Circulating immune cells, which are recruited to the site of injury/disease, secrete various inflammatory mediators that are critical to nociception and pain. The role of tissue-resident immune cells, however, remains poorly characterized. One of the first cells to be activated in peripheral tissues following injury are γδT cells, which serve important roles in infection, disease, and wound healing. Using a mouse line lacking these cells, we sought to identify their contribution to inflammatory pain. Three distinct models of peripheral inflammatory pain were used: intraplantar injection of formalin (spontaneous inflammatory pain), incisional wound (acute inflammatory pain), and intraplantar injection of complete Freund's adjuvant (chronic inflammatory pain). Our results show that absence o

SUBMITTER: Petrovic J 

PROVIDER: S-EPMC6431614 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature