Pharmacokinetic and Pharmacogenetic Factors Contributing to Platelet Function Recovery After Single Dose of Ticagrelor in Healthy Subjects.

ABSTRACT: Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related to pharmacokinetics on the recovery of platelet function after single dose of ticagrelor was orally administered to healthy Chinese subjects. Methods: The pharmacokinetic profiles of ticagrelor and its metabolite AR-C124910XX (M8), and the platelet aggregation (PA), were assessed after 180 mg of single-dose ticagrelor was orally administered to 51 healthy Chinese subjects. Effects of CYP2C19 ^* 2, CYP2C19 ^* 3, CYP3A5 ^* 3, UGT1A1 ^* 6, UGT1A1 ^* 28, UGT2B7 ^* 2, UGT2B7 ^* 3, SLCO1B1 388A>G, and SLCO1B1 521T>C, on the pharmacoki

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC6431676 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature