Proton-pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia.

ABSTRACT:

Background

Proton-pump inhibitors (PPIs) are commonly used in clinical practice for gastric acid suppression. However, these agents have also been associated with certain negative clinical outcomes. We evaluated the real-world effects of incident PPI use on clinical outcomes in patients with Staphylococcus aureus bacteremia.

Methods

This retrospective cohort study included patients admitted to Veterans Affairs hospitals with positive S. aureus blood cultures collected between 2002 and 2013 that received appropriate antibiotics within 48 hours of culture collection. Clinical outcomes among three PPI exposure groups, each compared to nonusers, were assessed with propensity-score-matched Cox proportional-hazard regression models: pretreated PPI users initiating th

SUBMITTER: Caffrey AR 

PROVIDER: S-EPMC6431768 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature