Glycoconjugate synthesis using chemoselective ligation.

ABSTRACT: Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

SUBMITTER: Cheng S 

PROVIDER: S-EPMC6431789 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature