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Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers.

ABSTRACT: Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer from a hydrophobic continuous phase to an aqueous continuous phase. We describe here a new strategy for the synthesis of a surfactant for inverse miniemulsions by radical addition⁻fragmentation chain transfer (RAFT) polymerization, which consists in a homopolymer with triisopropylsilyl protecting groups. The protecting groups ensure the efficient stabilization of the inverse (water-in-oil, w/o) miniemulsions. Nanocapsules can be formed and the protecting group can be subsequently cleaved for the re-dispersion of nanocapsules in an aqueous medium with a minimal amount of additional surfactant.

SUBMITTER: Wald S

PROVIDER: S-EPMC6431836 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Stabilization of Inverse Miniemulsions by Silyl-Protected Homopolymers.

Wald Sarah S Wurm Frederik R FR Landfester Katharina K Crespy Daniel D

Polymers 20160812 8

Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer from a hydrophobic continuous phase to an aqueous continuous phase. We describe here a new strategy for the synthesis of a surfactant for inverse miniemulsions by radical addition⁻fragmentation chain ...[more]

PMID: 30974578

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