Synthesis of Novel Temperature- and pH-Sensitive ABA Triblock Copolymers P(DEAEMA-co-MEO₂MA-co-OEGMA)-b-PEG-b-P(DEAEMA-co-MEO₂MA-co-OEGMA): Micellization, Sol⁻Gel Transitions, and Sustained BSA Release.

ABSTRACT: Novel temperature- and pH-responsive ABA-type triblock copolymers, P(DEAEMA-co-MEO₂MA-co-OEGMA)-b-PEG-b-P(DEAEMA-co-MEO₂MA-co-OEGMA), composed of a poly(ethylene glycol) (PEG) middle block and temperature- and pH-sensitive outer blocks, were synthesized by atom transfer radical polymerization (ATRP). The composition and structure of the copolymer were characterized by ¹H NMR and gel permeation chromatography (GPC). The temperature- and pH-sensitivity, micellization, and the sol⁻gel transitions of the triblock copolymers in aqueous solutions were studied using transmittance measurements, surface tension, viscosity, fluorescence probe technique, dynamic light scattering (DLS), zeta-potential measurements, and transmission electron microscopy (TEM). T

SUBMITTER: Han Y 

PROVIDER: S-EPMC6431942 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature