CD95-ligand contributes to abdominal aortic aneurysm progression by modulating inflammation.

ABSTRACT:

Aims

Abdominal aortic aneurysm (AAA) is one of the number of diseases associated with a prominent inflammatory cell infiltration, matrix protein degradation, and smooth muscle cell apoptosis. CD95 is an inflammatory mediator and an apoptosis inducer. Previous studies have shown elevated expression of CD95 or CD95L in the aortic tissue of AAA patients. However, how the CD95L/CD95 contributes to aneurysm degeneration and whether blocking its signalling would be beneficial to disease progression remains largely unknown. In the present study, we sought to determine the role of CD95L and its downstream target, caspase 8, in AAA progression.

Methods and results

By using the CaCl2 murine model of AAA, abdominal aortic aneurysms were induced in C57BL/6 mice. We found that both mRNA

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6432056 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature