Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.

ABSTRACT: Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only

SUBMITTER: Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: [e-mail] 

PROVIDER: S-EPMC6432650 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature