Long-term Immunotoxic Effects of Oral Prenatal and Neonatal Atrazine Exposure.

ABSTRACT: Atrazine and its metabolites are present at high concentrations in many water supplies in agro-intensive areas. Because residents in these areas drink water from sources fed from these contaminated supplies, we investigated the long-term immunotoxicity of combined prenatal and neonatal (perinatal) exposure to atrazine via drinking water, on the immune system in mice. At 6 months of age, upon immunization with heat-killed Streptococcus pneumoniae, the serum IgG antibody response against the T independent antigen phosphorylcholine was significantly higher in male, but not female, atrazine-exposed mice as compared with that in untreated controls. No alterations were present in all offspring in the serum antibody response against the T-dependent antigen pneumococcal surface protein A (PspA). E

SUBMITTER: Holaskova I 

PROVIDER: S-EPMC6432865 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature