Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

ABSTRACT:

Objectives

To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary respiratory failure.

Design

Prospective pharmacokinetic-pharmacogenomic observational study.

Setting

Thirteen PICUs across the United States.

Patients

Pediatric subjects mechanically ventilated for acute respiratory failure, weight greater than or equal to 7 kg, receiving morphine and/or midazolam continuous infusions.

Interventions

Serial blood sampling for drug quantification and a single blood collection for genomic evaluation.

Measurements and main results

Concentrations of midazolam, the 1' (1`-hydroxymidazolam metabolite) and 4' (4`-hydroxymidazolam metabolite) hydroxyl, and the 1' and 4' glucuronide metabolites were

SUBMITTER: Zuppa AF 

PROVIDER: S-EPMC6432942 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature