Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders.

ABSTRACT: Studies of the genetics of psychiatric disorders have become one of the most exciting and fast-moving areas in human genetics. A decade ago, there were few reproducible findings, and now there are hundreds. In this review, we focus on the findings that have illuminated the genetic architecture of psychiatric disorders and the challenges of using these findings to inform our understanding of pathophysiology. The evidence is now overwhelming that psychiatric disorders are "polygenic"-that many genetic loci contribute to risk. With the exception of a subset of those with ASD, few individuals with a psychiatric disorder have a single, deterministic genetic cause; rather, developing a psychiatric disorder is influenced by hundreds of different genetic variants, consistent with a polygenic model

SUBMITTER: Sullivan PF 

PROVIDER: S-EPMC6432948 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature