4-Aminopyridine as a Single Agent Diagnostic and Treatment for Severe Nerve Crush Injury.

ABSTRACT:

Background

Traumatic peripheral nerve injury (TPI) is a major medical problem without effective treatment options. There is no way to diagnose or treat an incomplete injury and delays contribute to morbidity. We examined 4-aminopyridine (4-AP), a potassium-channel blocker as a possible treatment for TPI.

Methods

We used standard mouse models of TPI with functional outcomes including sciatic-functional-index, sensory indices, and electrodiagnostics; in addition to standard immunohistochemical, and electron microscopic correlates of axon and myelin morphology.

Results

Sustained early 4-AP administration increased the speed and extent of behavioral recovery too rapidly to be explained by axonal regeneration. 4-AP also enhanced recovery of nerve conduction velocity, promo

SUBMITTER: Noble M 

PROVIDER: S-EPMC6433095 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature