Effects of Positive End-Expiratory Pressure and Spontaneous Breathing Activity on Regional Lung Inflammation in Experimental Acute Respiratory Distress Syndrome.

ABSTRACT:

Objectives

To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on regional lung inflammation in experimental nonsevere acute respiratory distress syndrome.

Design

Laboratory investigation.

Setting

University hospital research facility.

Subjects

Twenty-four pigs (28.1-58.2 kg).

Interventions

In anesthetized animals, intrapleural pressure sensors were placed thoracoscopically in ventral, dorsal, and caudal regions of the left hemithorax. Lung injury was induced with saline lung lavage followed by injurious ventilation in supine position. During airway pressure release ventilation with low tidal volumes, positive end-expiratory pressure was set 4 cm H2O above the level to

SUBMITTER: Kiss T 

PROVIDER: S-EPMC6433156 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature