Systematic review of therapeutic nipple-sparing versus skin-sparing mastectomy.

ABSTRACT:

Background

The use of nipple-sparing mastectomy (NSM) is increasing, despite unproven oncological safety in the therapeutic setting. The aim of this systematic review was to determine the safety and efficacy of NSM compared with skin-sparing mastectomy (SSM).

Methods

A literature search of all original studies including RCTs, cohort studies and case-control studies comparing women undergoing therapeutic NSM or SSM for breast cancer was undertaken. Primary outcomes were oncological outcomes; secondary outcomes were clinical, aesthetic, patient-reported and quality-of-life outcomes. Data analysis was undertaken to explore the relationship between NSM and SSM, and preselected outcomes. Heterogeneity was assessed using the Cochrane tests.

Results

A total of 690 articles w

SUBMITTER: Agha RA 

PROVIDER: S-EPMC6433323 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature