Distinct progenitor populations mediate regeneration in the zebrafish lateral line.

ABSTRACT: Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage. These renewed hair cells arise from the proliferation of surrounding support cells, which undergo symmetric division to produce two hair cell daughters. Given the continued regenerative capacity of the lateral line, support cells presumably have the ability to replenish themselves. Utilizing novel transgenic lines, we identified support cell populations with distinct progenitor identities. These populations show differences in their ability to generate new hair cells during homeostasis and regeneration. Targeted ablation of support cells reduced the number of regenerated hair cells. Furthermore, progenitors regenerated after targeted support cell ablation in the absence of hair cell damage. We also

SUBMITTER: Thomas ED 

PROVIDER: S-EPMC6433462 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature