Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark.

ABSTRACT: OBJECTIVES:Previous research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS. METHODS:ALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex. RESULTS:For men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher duri

SUBMITTER: Dickerson AS 

PROVIDER: S-EPMC6433465 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature