The cadherin-catenin complex is necessary for cell adhesion and embryogenesis in Nematostella vectensis.

ABSTRACT: The cadherin-catenin complex is a conserved, calcium-dependent cell-cell adhesion module that is necessary for normal development and the maintenance of tissue integrity in bilaterian animals. Despite longstanding evidence of a deep ancestry of calcium-dependent cell adhesion in animals, the requirement of the cadherin-catenin complex to coordinate cell-cell adhesion has not been tested directly in a non-bilaterian organism. Here, we provide the first analysis of classical cadherins and catenins in the Starlet Sea Anemone, Nematostella vectensis. Gene expression, protein localization, siRNA-mediated knockdown of α-catenin, and calcium-dependent cell aggregation assays provide evidence that a bonafide cadherin-catenin complex is present in the early embryo, and that α-catenin is required fo

SUBMITTER: Nathaniel Clarke D 

PROVIDER: S-EPMC6433513 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature