Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances.

ABSTRACT: Intrahepatic cholangiocarcinoma (iCCA) has over the last 10-20 years become the focus of increasing concern, largely due to its rising incidence and high mortality rates worldwide. The significant increase in mortality rates from this primary hepatobiliary cancer, particularly over the past decade, has coincided with a rapidly growing interest among clinicians, investigators, and patient advocates to seek greater mechanistic insights and more effective biomarker-driven targeted approaches for managing and/or preventing this challenging liver cancer. In addition to discussing challenges posed by this aggressive cancer, this review will emphasize recent epidemiological, basic, and translational research findings for iCCA. In particular, we will highlight emerging demographic changes and evol

SUBMITTER: Sirica AE 

PROVIDER: S-EPMC6433548 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature