Association mapping desiccation resistance within chromosomal inversions in the African malaria vector Anopheles gambiae.

ABSTRACT: Inversion polymorphisms are responsible for many ecologically important phenotypes and are often found under balancing selection. However, the same features that ensure their large role in local adaptation-especially reduced recombination between alternate arrangements-mean that uncovering the precise loci within inversions that control these phenotypes is unachievable using standard mapping approaches. Here, we take advantage of long-term balancing selection on a pair of inversions in the mosquito Anopheles gambiae to map desiccation tolerance via pool-GWAS. Two polymorphic inversions on chromosome 2 of this species (denoted 2La and 2Rb) are associated with arid and hot conditions in Africa and are maintained in spatially and temporally heterogeneous environments. After measuring thousand

SUBMITTER: Ayala D 

PROVIDER: S-EPMC6433559 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature