Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice.

ABSTRACT:

Background and purpose

Sphingosine-1-phosphate 2 (S1P₂ ) receptors have been implicated in degranulation of mast cells. However, functions of S1P₂ receptors have not been investigated in an in vivo model of allergic asthma.

Experimental approach

Using an ovalbumin (OVA)-induced asthma model, the function of S1P₂ receptors was evaluated in S1P₂ -deficient mice or in mice treated with JTE-013, a selective S1P₂ antagonist. Bone marrow-derived dendritic cells (BMDCs) were used to investigate the roles of S1P₂ receptors in dendritic cell maturation and migration.

Key results

Eosinophil accumulation and elevated Th2 cytokine levels in bronchoalveolar lavage fluid and inflamed lung tissues were strongly inhibi

SUBMITTER: Park SJ 

PROVIDER: S-EPMC6433643 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature