MiR-802 causes nephropathy by suppressing NF-κB-repressing factor in obese mice and human.

ABSTRACT: Obesity is associated with significant microvascular complications including renal injuries and may induce end-stage renal disease. Emerging studies have demonstrated microRNAs (miRNAs) are potential mediators in the pathophysiological process of nephropathy. The present study aimed to investigate the role of miR-802 in obesity-related nephropathy and potential molecular mechanisms. Through utilizing obese mouse model and human subjects, we explored the therapeutic benefits and clinical application of miR-802 in protecting against nephropathy. Renal miR-802 level was positively correlated with functional parameters, including blood urea nitrogen and creatinine in obese mice. Specific silencing of renal miR-802 improved high fat diet (HFD)-induced renal dysfunction, structural disorders and

SUBMITTER: Sun D 

PROVIDER: S-EPMC6433720 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature