Proteomics Study of Peripheral Blood Mononuclear Cells (PBMCs) in Autistic Children.

ABSTRACT: Autism is one of the most common neurological developmental disorder associated with social isolation and restricted interests in children. The etiology of this disorder is still unknown. There is neither any confirmed laboratory test nor any effective therapeutic strategy to diagnose or cure it. To search for biomarkers for early detection and exploration of the disease mechanisms, here, we investigated the protein expression signatures of peripheral blood mononuclear cells (PBMCs) in autistic children compared with healthy controls by using isobaric tags for relative and absolute quantitation (iTRAQ) proteomics approach. The results showed a total of 41 proteins as differentially expressed in autistic group as compared to control. These proteins are found associated with metabolic pathwa

SUBMITTER: Shen L 

PROVIDER: S-EPMC6433831 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature