Region-specific association between basal blood insulin and cerebral glucose metabolism in older adults.

ABSTRACT: BACKGROUND:Although previous studies have suggested that insulin plays a role in brain function, it still remains unclear whether or not insulin has a region-specific association with neuronal and synaptic activity in the living human brain. We investigated the regional pattern of association between basal blood insulin and resting-state cerebral glucose metabolism (CMglu), a proxy for neuronal and synaptic activity, in older adults. METHOD:A total of 234 nondiabetic, cognitively normal (CN) older adults underwent comprehensive clinical assessment, resting-state 18F-fluodeoxyglucose (FDG)-positron emission tomography (PET) and blood sampling to determine overnight fasting blood insulin and glucose levels, as well as apolipoprotein E (APOE) genotyping. RESULTS:An exploratory voxel-wise anal

SUBMITTER: Byun MS 

PROVIDER: S-EPMC6434096 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature