Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice.

ABSTRACT: Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined with pre- and postoperative multidrug chemotherapy and/or radiotherapy, and is still associated with high recurrence rates. The development of cellular strategies against specific characteristics of tumour cells appears to be promising, as they can target cancer cells selectively. Recently, Mesenchymal Stromal Cells (MSCs) have been the subject of significant research in orthopaedic clinical practice through their use in regenerative medicine. Further research h

SUBMITTER: Stamatopoulos A 

PROVIDER: S-EPMC6434099 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature