High-Throughput Mutation Data Now Complement Transcriptomic Profiling: Advances in Molecular Pathway Activation Analysis Approach in Cancer Biology.

ABSTRACT: We recently reviewed the current progress in the use of high-throughput molecular "omics" data for the quantitative analysis of molecular pathway activation. These quantitative metrics may be used in many ways, and we focused on their application as tumor biomarkers. Here, we provide an update of the most recent conceptual findings related to pathway analysis in tumor biology, which were not included in the previous review. The major novelties include a method enabling calculation of pathway-scale tumor mutation burden termed "Pathway Instability" and its application for scoring of anticancer target drugs. A new technique termed Shambhala emerged that enables accurate common harmonization of any number of gene expression profiles obtained using any number of experimental platforms. This ma

SUBMITTER: Buzdin A 

PROVIDER: S-EPMC6434430 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature