The evaluation of phenylalanine levels in Estonian phenylketonuria patients during eight years by electronic laboratory records.

ABSTRACT: Blood phenylalanine (Phe) values from the dried blood spots of all Estonian phenylketonuria (PKU) patients have been deposited into a unified electronic laboratory database for eight years, providing an opportunity to assess the adherence of the patients to dietary recommendations over time and to observe patient practices both individually and collectively. Our results demonstrate generally good adherence to clinical and dietary recommendations during the first six years of life, as the percentage of patients with median Phe values fitting under the national recommendation levels were 95%, 84% and 70% in age groups 0-1, 1-2 and 2-6 years, respectively. Conversely, significant deviations occur in the group of 6 to 12 year-olds, mildly decreasing in adolescence and increasing in adulthood (

SUBMITTER: Lillevali H 

PROVIDER: S-EPMC6434493 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature