Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses.

ABSTRACT:

Editor's note

Please see the Editor's Note (doi: https://doi.org/10.1136/bmj.l1042) on Methodological Criticism and an Updated Analysis

Objective

To investigate the shape of the causal relation between body mass index (BMI) and mortality.

Design

Linear and non-linear mendelian randomisation analyses.

Setting

Nord-Trøndelag Health (HUNT) Study (Norway) and UK Biobank (United Kingdom).

Participants

Middle to early late aged participants of European descent: 56 150 from the HUNT Study and 366 385 from UK Biobank.

Main outcome measures

All cause and cause specific (cardiovascular, cancer, and non-cardiovascular non-cancer) mortality.

Results

12 015 and 10 344 participants died during a median of 18.5 and 7.0 years of follow-up in the HUNT Study

SUBMITTER: Sun YQ 

PROVIDER: S-EPMC6434515 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature