Adult outcomes of childhood disruptive disorders in offspring of depressed and healthy parents.

ABSTRACT:

Background

Longitudinal studies of children with disruptive disorders (DDs) have shown high rates of antisocial personality disorder (ASPD) and substance use in adulthood, but few have examined the contribution of parental disorders. We examine child-/adulthood outcomes of DDs in offspring, whose biological parents did not have a history of ASPD, bipolar disorder, or substance use disorders.

Method

Offspring (N = 267) of parents with or without major depression (MDD), but no ASPD or bipolar disorders were followed longitudinally over 33 years, and associations between DDs and psychiatric and functional outcomes were tested.

Results

Eighty-nine (33%) offspring had a DD. Those with, compared to without DDs, had higher rates of MDD (adjusted odds ratio, AOR = 3.42, p < 0

SUBMITTER: Diaz AP 

PROVIDER: S-EPMC6434691 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature