Genomic comparison of serogroups O159 and O170 with other Vibrio cholerae serogroups.

ABSTRACT:

Background

Of the hundreds of Vibrio cholerae serogroups, O1 and O139 are the main epidemic-causing ones. Although non-O1/non-O139 serogroups rarely cause epidemics, the possibility exists for strains within them to have pathogenic potential.

Results

We selected 25 representative strains within 16 V. cholerae serogroups and examined their genomic and functional characteristics. We tentatively constructed a gene pool containing 405 homologous gene clusters, which is well organized and functions in O-antigen polysaccharide (O-PS) synthesis. Our network analysis indicate that great diversity exists in O-PS among the serogroups, and several serogroup pairs share a high number of homologous genes (e.g., O115 and O37; O170 and O139; O12 and O39). The phylogenetic analysis results

SUBMITTER: Li Z 

PROVIDER: S-EPMC6434791 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature